Dermatology research 2024
Dermatology innovations

Say No to “minoxidil for life”

A multi-factorial disease to be reckoned with in several grounds

alopecia areata

While alopecia areata has been recognized as an auto-immune disorder, androgenic Alopecia appears to be the most common form of male and female hair shedding which affects 50% of men by the age 50 and 50% of women by the age 60. Advances in biology of hair loss at molecular level provided better understanding of causes of hair loss and a new approach to its treatment. This approach involves inhibition of 5-alpha reductase, the enzyme which reduces testosterone to its more active form, dihydro testosterone.

Adherens and desmosomesActivation of autoantigens and upregulation of NKG2DL and MHCI in keratinocytes and melanocytes is followed by expression of NKG2D by CDH8+ cells which leads to release of IF-gamma, IL-5 and IL-12 and granzyme b (GZM) and eventuall activation of JAK-STAT pathway.

Interleukin 17 in alopecia areata

Dihydrotestosterone is currently thought to be the most potent androgen affecting the human hair growth cycle, with adverse effects in male pattern hair loss. A recent study suggests role of interleukin-17 in androgenic alopecia and inhibition of this inflammatory maker as a potential treatment for hair loss.

Estrogen effect and female hair loss

Hair loss in women: Given the protective effect of estrogen and progesterone, there are female hair thinning, which are due to hormonal imbalance and increased DHT level as well. DHT blockers such as Follicle Treatment, an anti aging hair loss serum, enjoying natural ingredients stimulates hair growth by blocking androgen receptors and enzyme 5-alpha reductase, which in turn reduces DHT production in both men and women.
Androgenic alopecia appear to be less severe and less frequent in females due to less expression, about as half, of 5-alpha-reductase and androgen receptors in females compare to males counterpart. In addition, aromatase activity in female hair follicles promotes conversion of testosterone to estradiol rather than DHT.

Causes of hair loss in women and men appear to be stress and life style related to a great extent and anti aging approaches and life style modifications which aim to contain lipid peroxidation and oxidative stress are perceived to be a rational strategy in treatment of alopecia areata in men as well as women.
hair follicle stress and life styleHow hair loss and hair follicle control mechanisms relates to life style, stress and aging

DHT blockers mechanisms of action

Blockers of dihydrotestosterone use different mechanisms to reduce dihydrotestosterone, among them are:

Blocking the alpha receptors in the hair follicles
Inhibition of the enzyme 5 alpha reductase, responsible for conversion of testosterone into DHT

Reducing the production of DHT

Reducing the substances that can produce the enzyme 5 alpha reductase like cholesterol
In susceptible hair follicles, dihydrotestosterone binds to the androgen receptor, and the hormone-receptor complex activates the genes responsible for the gradual transformation of large terminal follicles to miniaturized follicles. Both young women and young men with androgenic alopecia have higher levels of 5-alpha reductase and androgen receptor in frontal hair follicles compared to occipital follicles. At the same time, young women have much higher levels of cytochrome p-450 aromatase in frontal follicles than men who have minimal aromatase, and women have even higher aromatase levels in occipital follicles.

Atopy association with hair loss

Twice more common than general population is the incidence rate of atopic dermatitis in alopecia areata patients, who are also at 43% increased risk of new onset atopic dermatitis, a large population-based study of two cohorts of 40,255 subjects has found.While alopecia areata has been perceived an auto-immune disorder, its association with atopy directs us to come up with treatments which also address atopic disease.
Adherens and desmosomesPresence of CD4 and CD8 T cells in perifollicular and intrafollicular areas in alopecia areata, with expression of NKG2D and CXCR3 by CD8 T cells.

One study suggests increased expression of CD4 cells, CCR6+ CD4 cells, which are essential for CD8 cells priming, in alopecia areata patients to provide rationale for role of atopy in the pathology of the disease. A 48-week double blind multi-center study on efficacy of dupilumab, further delivered results indicating 30% improvement in SALT score, substantianting role of atopy in pathogenesis of alopecia areata. Dupilumab is a monoclonal antibody which binds alpha subunit of IL-4.

Anti aging hair loss serum

Follicle Treatment, our anti aging hair loss serum, a natural DHT blocker is an anti aging solution to male and female pattern hair loss. This anti aging hair loss product is based on latest medical research on causes of hair loss in women and men. It is now known that dihydrotestosterone (DHT), a by-product of testosterone, is the detrimental agent that may be a hair loss cause. Simply put, under certain conditions DHT “strangles” hair follicles>
Most recent hair loss research has proven that DHT is responsible for the progressive shrinking of the hair follicle. While this process is the primary cause of hair loss in women, there are several other factors that contribute to further deterioration of the hair follicle.

Oxidative stress, reactive oxygen species and free radical generation may account for hair thinning and loss to a significant degree. Nutrient deficient hair follicles, poor circulation of the scalp, over active sebaceous glands, and clogged or harshly treated hair follicles are among these factors.

Follicle Treatment Benefits:

  • Stimulates hair follicle by blocking 5-alpha reductase and androgen receptors, hair loss treatment serum causes a local reduction in DHT( a recognized hair loss cause) level
  • Renews scalp and unclogs follicles
  • Reactivates follicle growth by restoring metabolic processes implicated in hair regeneration
  • Nourishes the follicles using the ingredients it needs most, gamma linolenic acid
  • Increases scalp micro-circulation and oxygenation of follicles, anti aging hair loss serum regenerates hair follicles by taking advantage of growth factors

Growth factors are leveraged in anti aging hair loss serum

Growth factors contribute to transition from follicular stem cells to hair follicle cells by supporting angiogenesis and making provisions to cells depleted in oxygen and nutrients through stress and aging, promoting telogen to anagen phase switch within hair follicles. Among a plethora of growth factos, IGF-1, insulin-like growth factor-1, TGF-β, transforming growth factor-beta, EGF, epithelial growth factor, PDGF, platelet-derived growth factor, VEGF, vascular endothelial growth factor have been more researched and more data is available on their profiles.

While growth factors are implicated in cell signaling and cell proliferation, they also exert an anti inflammatory perfomance by releasing IL-1 antagonist receptor, sTNF, soluble TNF receptor, IL-4, IL-10 and IL-13, which is another aspect of cascade of events imparting to hair loss.

hair regenerating follicle treatment to manage alopecia areata and hair thinning in men and womenFollicle treatment leverages growth factors and multitude of anti aging elements to allow regeneration of hair follicle by restoring mechanisms implicated in normal homeostasis of pilosebaceous unit as well as dermal and epidermal metabolic functions