Dermatology research 2024
Dermatology innovations

Dermal Repair

Dermis layer, firming serum most immediate target

Skin regeneration focusing on restoration of cutaneous metabolic functions

Deterioration of collagen and other constituents of skin’s connective tissue in the form of degradation and fragmentation is characteristic of skin aging process. Ambition of the firming serum, dermal repair, directs toward attenuation of processes invoking cutaneous senescence or the ones which grow indolent consequent to aging. Starts as early as age 25, the skin aging process slowly and continuously causes several changes in appearance and characteristics of the skin. The following are among these changes:

skin changes with aging progress

  • Slower skin renewal (turnover of skin surface) result in slower wound healing, dermal repair and formation of fine lines
  • Damage to collagen and elastin network of fibers causes the skin to lose its strength and elasticity
  • Skin becomes drier as a result of decrease in the number of moisture holding glycosaminoglycans
  • Reduction in the number of blood vessels causes the skin to receive less oxygen and nutrients, leaving the skin dull and glowless
  • Reduction in subcutaneous fat render the skin looks less plump
  • stress and force of gravity also pulling at the skin and results in more sagging skin

Cellular as opposed to non-cellular regeneration techniques

While attempt have been made in medical research for tissue regeneration using multipotent stem cells, there always have been understated risks of tumor formation and immune system rejection associated with their utilization. As a result, paracrine substances by the same mesenchymal cells have been employed with clearly more substantial safety profiles that can modulate tissue regeneration and dermal repair. A non-cellular approach using growth factors and extracellular vesicles have been more successfully adventured to accomplish a task with results unequivocal to what long have been experienced.

dermatology innovative skin care products to treat and manage burden of the disease

Oxidative stress

The effect of vitamin C on skin has been long revealed by medical science. Vitamin C in the form of L-ascorbic acid affects skin in two ways. First by neutralizing free radicals caused by sun exposure, smoking and stress, second by helping the collagen synthesis in skin cells. The net result is more firm resilient skin. Vitamin C in order to work requires to be in the form of L-Ascorbic acid. As valuable as it is known, vitamin C by itself carry no palpable or meaningful impact on aging skin or dermal repair, it is only in more complex formulations that its virtue looms in.
- aging reactive oxygen speciesReactive oxygen species formation as a result of aging and sun exposure. Formation of matrix metaloproteinases with resultant collagen degradation and elastosis which eventually leads to senescent fibroblasts is illustrated concurrent with inhibition of TGF-beta within nucleus of young fibroblasts by nuclear factor kappaB which stalls collagen synthesis.

Firming serum of dermal repair complex

These criteria all met in Day Treatment, dermal repair complex, which is a growth-factor based serum for skin firming. In fact, dermal repair complex serum is fortified with bioflavanoids to combat skin ‘s lipid peroxidation integrated into a firming serum with ascorbic acid in the most desirable form, ascorbyl phosphate. This serum works in synergy with night serum, a skin resurfacing serum which primarily points to wrinkles and facial lines.